Bridging Cognitive Decline and Cardiovascular Health for Healthy Aging
An AI-driven approach to prevent Mild Cognitive Impairment (MCI) in cardiovascular patients
The Overlapping Burden of MCI and CVD
The Rising Intersection of Cardiovascular Disease (CVD) and Cognitive Decline in Aging Populations
MCI and CVD are increasingly prevalent and often co-occur in the aging population. An estimated one-third of CVD patients also experience cognitive impairment.
The Combined Toll of MCI and CVD: Effects on Quality of Life, Prognosis, and Mortality
The co-occurrence of MCI and CVD may have a cumulative effect, significantly impacting quality of life and prognosis. MCI can increase mortality rates in hypertensive patients by up to 14.6%.
Undiagnosed Risk
Early detection gaps in CVD patient
MCI goes unrecognized in 50–80% of cardiovascular patients, delaying critical interventions.
Despite its prevalence, MCI often remains undiagnosed in CVD patients. Early detection could help slow progression, but current medical guidance is limited to optimizing therapy rather than proactive intervention.
Data-Driven Prevention
Bridging clinical assessments and real-world data
Standard diagnostic methods lack the sensitivity to detect early cognitive decline.
Integrating real-world data from remote monitoring with clinical assessments is crucial to identifying subtle cognitive changes in the early stages of MCI. A more precise, data-driven approach is needed for personalized prevention.
Beyond Medication
Personalized, multidomain strategies for MCI prevention
Pharmacological solutions remain inconclusive, requiring a broader intervention model.
With limited evidence supporting drug-based cognitive enhancement, alternative strategies like lifestyle interventions, risk stratification, and neuroimaging-based assessments are essential to improving patient outcomes.
Bridging Science and Innovation
DORIAN GRAY: A Smarter Approach to Brain & Heart Health
Cardiovascular and cognitive health are deeply connected, yet MCI often goes undetected in CVD patients. DORIAN GRAY is transforming prevention by integrating cutting-edge research, AI, and digital tools to provide early risk detection and personalized interventions.
AI-Powered Risk Assessment
Using real-world data from wearables and clinical evaluations, DORIAN GRAY’s Digital Twin technology identifies patterns that help predict cognitive decline. This data-driven model supports healthcare professionals in risk stratification and enables personalized prevention strategies.
Personalized, Multi-Domain Prevention
Rather than relying on a single approach, DORIAN GRAY tailors interventions by combining:
- Advanced AI modeling to assess individual risks
- Behavioral coaching for sustainable lifestyle changes
- Digital biomarkers for continuous health monitoring
These strategies empower both healthcare providers and individuals to take proactive steps in maintaining cognitive and cardiovascular health.
A New Way to Engage in Prevention
The Avatar-Based Coaching Exergame (ABCE) turns health management into an interactive experience. Designed for both patients and professionals, it enhances cognitive function while encouraging active participation in prevention strategies.
The Future of Healthy Aging
DORIAN GRAY is setting a new standard in preventative healthcare, leveraging AI and digital tools to create a future where cognitive decline can be detected and addressed before it impacts daily life.
Consortium
A Global Network Driving Innovation in Health and Well-being
A multidisciplinary consortium of leading academic institutions, research centers, healthcare providers, and industry partners, all united by a shared mission: to revolutionize the prevention and management of mild cognitive impairment (MCI) in patients with cardiovascular diseases (CVD).
By integrating expertise from artificial intelligence, neurology, cardiology, digital health, and behavioral sciences, our network is uniquely positioned to develop cutting-edge solutions for personalized risk assessment and holistic intervention strategies.
